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Postdoctoral positions

Postdoctoral positions

Les dernières offres de stages, de thèses ou encore de post-docs du LP2N sont disponibles ici : http://www.lp2n.fr/category/offres/

Postdoctoral position in "Electromagnetic theory and modeling"

One-year post-doctoral position in the group “Light in Complex Nanostructures” at LP2N

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Disordered ensembles of complex, strongly resonating nanoparticles in planar geometries are ubiquitous in emerging photonic materials and devices. Their high scientific and technological potential is due to the richness of their optical properties, coming from the individual nanoparticles, their interaction with a structured substrate (a thin-film stack) and their mutual interaction at both short and long ranges. Theoretically predicting the optical properties of such complex nanostructures has however remained a seemingly insurmountable challenge up to now, due to the difficulty to consider simultaneously the coherent phenomena occurring down to the nano-scale – at the level of the individual nanoparticle – up to the mesoscopic scale – at the level of the nanoparticle ensemble.

In this project, we will explore a new approach based on a modal formalism to unlock the key modeling challenges posed by complex optical stacks and develop the first numerical tool able to predict their optical properties. The project is very challenging, yet a successful outcome would enable the design of nanostructured surfaces, fabricable by bottom-up techniques (hence at low cost and on large scales), producing new targeted optical functions. Our research could impact technologies as diverse as photovoltaic panels, organic light-emitting diodes, biosensors, transparent displays for augmented reality, and optical materials engineering for interior design.

The post-doctoral fellow is expected to have advanced skills in optical physics and computational electromagnetics. The one-year post-doctoral position may be extended to a second year, depending on the results of the first year and the funding availability.

Candidates should send their application, including CV and reference contacts, to kevin.vynck@institutoptique.fr and philippe.lalanne@institutoptique.fr.

Starting date: Before June 1st, 2016.

Additional information on the group
https://www.lp2n.institutoptique.fr/Membres-Services/Responsables-d-equipe/LALANNE-Philippe

Location
LP2N, Institut d'Optique d'Aquitaine, rue François Mitterrand, 33400 Talence, France

Funding
This project is supported by the Cluster of Excellence LAPHIA of the University of Bordeaux.
http://laphia.labex.u-bordeaux.fr/en/

Postdoctoral position in "biophotonics"

The LP2N is recruiting a postdoctoral fellow to work in the research axis "Optics and Biology" on the project entitled "Light-sheet-based microscopy for imaging in vitro tumors and epithelia reconstituted by a microfluidic technique"

We have recently developed a platform to produce multicellular spheroids in a controlled and high throughput manner. These spheroids are aggregates of cancer cells and are recognized to mimic the behavior and growth of micro-tumors. The technology is inspired from a culinary creation, the Flavor Pearls, which were invented by a physico-chemist, J. Bibette, and the gastronomy chef Thierry Marx. It is based on the use of a co-extrusion microfluidic device and allows us to encapsulate cells and subsequently culture spheroids (of typically one hundred microns in radius). An extension of the method leads to the formation of cell monolayers that are closed on themselves in a spherical (cyst) or cylindrical (vessel) geometry. We wish to exploit these technological advances for engineering (healthy or pathological) tissues and to perform a comprehensive biophysical investigation of the fundamental growth and homeostasis mechanisms in biological tissues.

This multidisciplinary project requires to develop a versatile imaging technique that allows us 1) to visualize tissue growth in toto, in reduced phototoxicity conditions, 2) to monitor the cellular organization within the spheroid, but also 3) to interrogate the fast dynamics of molecular events within individual cells. The main objective of this project is thus to implement a light-sheet-based microscopy technique adapted to the geometry and optical biological constraints of living samples.

The successful applicant will have a lead role in experimental work that includes assembling this modular microscope and preparing our reconstituted tissues and tumors (in collaboration with biology experts). The ideal candidate will have a PhD in biophotonics, with a background in optics. Other trainings with experience in cell biology, microfluidics, optical microscopy or advanced, may also be appreciated.

For information or to submit your application (with CV and two letters of recommendation), please contact:

Pierre Nassoy (Email: pierre.nassoy@institutoptique.fr)

Post-doc-Nassoy en1 (DOCX / 14,83 kB)
Post-doc-Nassoy fr1 (DOCX / 14,69 kB)

Postdoctoral position in "biophotonics"

The LP2N is recruiting a postdoctoral fellow to work in the research axis "Optics and Biology" on the project entitled "Micromechanical, microfluidic and optical approaches of mechanotransduction in cancer cells".

We have recently demonstrated a new path of membrane tension regulation in living cells through caveolae, which are small membrane invaginations (Sinha et al., Cell, 2011). The constitutive protein, caveolin, is very abundant in all cells that experience chronic mechanical stress (e.g.: muscle cells contract, endothelial cells are sheared in blood vessels, and tumor cells are compressed in solid tumors). We now wish to dissect the mechanisms of caveolae-mediated mechanotransduction. To do so, we are developing various microfluidic devices and micro-mechanical assays to apply controlled external stresses to cells. To monitor the cellular response, we are using conventional optical microscopy (TIRF, confocal) and we will develop new imaging techniques combining light sheet optical sectioning and high speed imaging.

The post-doc will have recruited a leading role in the design of microfluidic devices and the construction of the optical set-up. The ideal candidate will have a PhD in biophysics or biophotonics, with physical training and marked motivation in biological issues. Other trainings with experience in cell biology, microfluidics or optics may also be appreciated.

For information or to submit your application (with CV and two letters of recommendation), please contact:

Pierre Nassoy (Email: pierre.nassoy@institutoptique.fr)

Post-doc-Nassoy en2 (DOCX / 14,03 kB)
Post-doc-Nassoy fr2 (DOCX / 14,44 kB)
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